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Article

Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes

1 Jun 1999

Abstract excerpt

Aneuploidy is a characteristic of the majority of human cancers, and recent work has suggested that mitotic checkpoint defects play a role in its development. To further explore this issue, we isolated a novel human gene, MAD2B (MAD2L2), which is homologous to the spindle checkpoint gene MAD2 (MAD2L1). We determined the chromosomal localization of it and other spindle checkpoint genes, including MAD1L1, MAD2,...

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Identifiers

PMID: 10366450
DOI: 10.1006/geno.1999.5831

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