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Article

Rb loss causes cancer by driving mitosis mad.

Cancer cell - 1 Jan 2007

van Deursen Jan M

Abstract excerpt

Aneuploidy is a hallmark of most human cancers, but whether it is a cause or a consequence of cellular transformation remains a subject of debate. The spindle checkpoint functions to prevent aneuploidy and plays a central role in this discussion. The checkpoint gene Mad2 is activated by E2F1 and overexpressed in cells lacking a functional Rb pathway. In this issue of Cancer Cell, Sotillo and coworkers report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17222786
DOI: 10.1016/j.ccr.2006.12.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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