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Article

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2.

Science (New York, N.Y.) - 27 Sept 2002

Martin-Lluesma Silvia, Stucke Volker M, Nigg Erich A

Abstract excerpt

The spindle checkpoint delays sister chromatid separation until all chromosomes have undergone bipolar spindle attachment. Checkpoint failure may result in chromosome mis-segregation and may contribute to tumorigenesis. We showed that the human protein Hec1 was required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores. Depletion of Hec1 impaired chromosome congression and caused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12351790
DOI: 10.1126/science.1075596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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