Article

S-phase kinase-associated protein 2 positively controls mitotic arrest deficient 2 in lung cancer cells

2016-07-18

Abstract excerpt

<h4>Background: </h4> . Mitotic arrest deficient 2 (Mad2) is a key component of spindle assembly checkpoint and overexpressed in human lung cancers, but the mechanism of the deregulation of Mad2 in lung cancer is largely unknown. We aim to investigate the regulation of Mad2 by S-phase kinase-associated protein 2 (Skp2) in human lung cancer cells. <h4>Methods: </h4>. Human lung cancer A549 and NCI-H1975 cells were...

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Literature Corpus work: 888634c3-e16b-5dda-9036-051b5a06aed1
DOI: 10.7287/peerj.preprints.2298v1

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