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Mutational Inactivation of Mitotic Checkpoint Genes, <i>hsMAD2</i> and <i>hBUB1</i>, Is Rare in Sporadic Digestive Tract Cancers

1 Aug 1999

Abstract excerpt

Genetic instability is a key mechanism of tumorigenesis, and the instability exists at two distinct levels, the nucleotide and the chromosome levels. Disruption of the mitotic spindle checkpoint is one of the underlying mechanisms leading to aneuploidy and alterations of hsMAD2 and hBUB1, assumed to take part in the spindle checkpoint in human cells, have been found to be associated with chromosomal instability...

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PMID: 10543255
DOI: 10.1111/j.1349-7006.1999.tb00824.x

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Mutational Inactivation of Mitotic Checkpoint Genes, <i>hsMAD2</i> and <i>hBUB1</i>, Is Rare in Sporadic Digestive Tract CancersPMID 10543255Read ↗

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