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Article

Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer.

Medical hypotheses - 1 Jul 1996

Shadan F F, Villarreal L P

Abstract excerpt

Genetic instability characterized by the accumulation of mutations of tumor suppressor genes and oncogenes appears to be associated with carcinogenesis in colorectal and other cancers. Mutations of DNA polymerase beta (pol beta) and related chromosomal alterations appear to be consistent with the causal role of a "mutator phenotype' in carcinogenesis. However, homozygous knockout pol beta mutations appear to...

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Source

Identifiers

PMID: 8819107
DOI: 10.1016/s0306-9877(96)90033-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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