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Article

Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase β

4 Aug 2009

Abstract excerpt

BACKGROUND: Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model. METHODOLOGY/PRINCIPAL FINDINGS: We have recently developed a novel transgenic mouse model that over-expresses Pol beta. These mice present with an elevated...

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PMID: 19654874
DOI: 10.1371/journal.pone.0006493

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