p53 mutations in head and neck squamous cell carcinomas from Sudanese snuff (toombak) users.

Article

p53 mutations in head and neck squamous cell carcinomas from Sudanese snuff (toombak) users.

Cancer detection and prevention - 1 Jan 1996

Lazarus P, Idris A M, Kim J, Calcagnotto A, Hoffmann D

Abstract excerpt

Toombak is a type of snuff used extensively in the Northern Sudan by a virtually non-smoking/nondrinking population. This Sudanese snuff contains inordinately high levels of the tobacco-specific nitrosamines (TSNAs) Nl-nitrosonornicotine (NNN) and (4-methylnitrosamino)-1-(3-pyridyl)-1-butanone (N...

Topics

Animals
Carcinogens
Carcinoma, Squamous Cell
Genes, p53
Genes, ras
Head and Neck Neoplasms
Humans
Mice
Mutation
Nitrosamines
Plants, Toxic
Polymorphism, Single-Stranded Conformational
Tobacco, Smokeless

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