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Article

Characteristics of mutations in the p53 gene of oral squamous-cell carcinomas associated with betel-quid chewing in Sri Lanka.

International journal of cancer - 11 Sept 1998

Chiba I, Muthumala M, Yamazaki Y, Uz Zaman A, Iizuka T, Amemiya A, Shibata T, Kashiwazaki H, Sugiura C, Fukuda H

Abstract excerpt

Oral squamous-cell carcinoma (SCC) is the most common neoplasm in Sri Lanka, accounting for approximately 30% of all cancers in males. Epidemiologic evidence indicates that there is an unequivocal relationship between betel chewing and oral carcinogenesis, suggesting that there may be specific ge...

Topics

Adult
Aged
Areca
Carcinoma, Squamous Cell
DNA Primers
DNA, Neoplasm
Exons
Female
Genes, p53
Humans
Male
Middle Aged
Mouth Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plants, Medicinal

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Sri Lanka

Source

Identifiers

PMID: 9714051
DOI: 10.1002/(sici)1097-0215(19980911)77:6<839::aid-ijc7>3.0.co;2-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9714051-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characteristics of mutations in the p53 gene of oral squamous-cell carcinomas associated with betel-quid chewing in Sri Lanka.PMID 9714051Read ↗

Some oral carcinomas from Sri Lankan betel/tobacco chewers overexpress p53 oncoprotein but lack mutations in exons 5-9.Semantic proximity Read ↗

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High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka.Semantic proximity Read ↗

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p53 alterations in betel quid- and tobacco-associated oral squamous cell carcinomas from Taiwan.Semantic proximity Read ↗

p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India.Semantic proximity Read ↗

Low prevalence of expression of p53 oncoprotein in oral carcinomas from Sri Lanka associated with betel and tobacco chewing.Semantic proximity Read ↗

Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan.Semantic proximity Read ↗

Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis.Semantic proximity Read ↗

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Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers.Semantic proximity Read ↗

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