Article
p53 gene mutations in oral carcinomas from India.
International journal of cancer - 3 May 1996
Munirajan A K, Tutsumi-Ishii Y, Mohanprasad B K, Hirano Y, Munakata N, Shanmugam G, Tsuchida N
Abstract excerpt
In this study, we analyzed 53 oral squamous-cell carcinomas among Indians for the presence of alterations in the tumor-suppressor gene p53 by PCR-SSCP and sequencing methods. Our results showed that 21% (11/53) of oral carcinomas analyzed carried mutations within the exons 5-8 of the p53 gene. We...
Topics
- Base Sequence
- Carcinoma, Squamous Cell
- DNA Mutational Analysis
- DNA Primers
- DNA, Neoplasm
- Exons
- Female
- Genes, p53
- Head and Neck Neoplasms
- Humans
- India
- Male
- Middle Aged
- Molecular Sequence Data
- Mouth Neoplasms
- Mutation
- Point Mutation
- Polymerase Chain Reaction