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Article

Mutations of the p53 gene in oral squamous-cell carcinomas from Sudanese dippers of nitrosamine-rich toombak and non-snuff-dippers from the Sudan and Scandinavia.

International journal of cancer - 17 May 1999

Ibrahim S O, Vasstrand E N, Johannessen A C, Idris A M, Magnusson B, Nilsen R, Lillehaug J R

Abstract excerpt

Using PCR-SSCP/DNA sequencing methods, we analyzed 14 oral squamous-cell carcinomas (OSCCs) and 8 pre-malignant oral lesions from different Sudanese patients for prevalence of mutations in exons 5 to 9 of the p53 gene in relation to toombak-dipping status. OSCCs (14 from Sudan, 28 from Scandinavia), and 3 pre-malignant oral lesions from Sudanese non-dippers were used as controls. A statistically significant...

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PMID: 10225439
DOI: 10.1002/(sici)1097-0215(19990517)81:4<527::aid-ijc4>3.0.co;2-2

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