Article
Low incidence of p53 mutations in betel quid and tobacco chewing-associated oral squamous carcinoma from India.
International journal of oncology - 1 Dec 1999
Kannan K, Munirajan A K, Krishnamurthy J, Bhuvarahamurthy V, Mohanprasad B K, Panishankar K H, Tsuchida N, Shanmugam G
Abstract excerpt
Mutations of the p53 tumor suppressor gene have been found to be the single most frequent event in human cancers. In India and other southeast Asian countries tobacco chewing with betel quid was attributed to be the major factor in oral carcinogenesis. We have analyzed 72 untreated primary oral squamous cell carcinomas (SCCs) for mutations in the tumor suppressor gene p53 exons 4-9 by PCR-SSCP and DNA sequencing....
Topics
- Adult
- Aged
- Aged, 80 and over
- Areca
- Base Sequence
- Carcinoma, Squamous Cell
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Humans
- Incidence
- India
- Male
- Middle Aged