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Article

Some oral carcinomas from Sri Lankan betel/tobacco chewers overexpress p53 oncoprotein but lack mutations in exons 5-9.

Anticancer research - 1 Jan 2000

Ranasinghe A, MacGeoch C, Dyer S, Spurr N, Johnson N W

Abstract excerpt

We reported a low prevalence (11%) of p53 expression detected by immunohistochemistry in oral squamous cell carcinomas associated with betel/tobacco chewing Sri Lankans (23). Five neoplasms which over-expressed p53 protein were used in the present study of mutations. Despite extensive sequence analysis no mutations were detected in exons 5 through 9 of the p53 gene in all the DNA samples of these neoplasms. Thus,...

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PMID: 8297114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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