Some oral carcinomas from Sri Lankan betel/tobacco chewers overexpress p53 oncoprotein but lack mutations in exons 5-9.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Some oral carcinomas from Sri Lankan betel/tobacco chewers overexpress p53 oncoprotein but lack mutations in exons 5-9.

Anticancer research - 1 Jan 2000

Ranasinghe A, MacGeoch C, Dyer S, Spurr N, Johnson N W

Abstract excerpt

We reported a low prevalence (11%) of p53 expression detected by immunohistochemistry in oral squamous cell carcinomas associated with betel/tobacco chewing Sri Lankans (23). Five neoplasms which over-expressed p53 protein were used in the present study of mutations. Despite extensive sequence an...

Topics

Areca
Base Sequence
DNA Primers
Exons
Gene Expression
Genes, p53
Head and Neck Neoplasms
Japan
Molecular Sequence Data
Mouth Neoplasms
Mutation
Plants, Medicinal
Plants, Toxic
Polymerase Chain Reaction
Sri Lanka
Tobacco, Smokeless
Tumor Suppressor Protein p53
United States

Source

Open in PubMed

Identifiers

PMID: 8297114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8297114-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics