Article
The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302.
Diabetes - 1 Nov 1997
Nejentsev S, Reijonen H, Adojaan B, Kovalchuk L, Sochnevs A, Schwartz E I, Akerblom H K, Ilonen J
Abstract excerpt
The genes encoding the HLA-DQ heterodimer molecules, DQB1 and DQA1, have been found to have the strongest association with IDDM risk, although there is cumulative evidence for the effect of other gene loci within the major histocompatibility complex gene region. After the HLA-DQ locus, the HLA-DR locus has been suggested most often as contributing to the disease susceptibility. In this study we analyzed at the...
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