Article
Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.
Tissue antigens - 1 Aug 2007
Thomson G, Valdes A M, Noble J A, Kockum I, Grote M N, Najman J, Erlich H A, Cucca F, Pugliese A, Steenkiste A, Dorman J S, Caillat-Zucman S, Hermann R, Ilonen J, Lambert A P, Bingley P J, Gillespie K M, Lernmark A, Sanjeevi C B, Rønningen K S, Undlien D E, Thorsby E, Petrone A, Buzzetti R, Koeleman B P C, Roep B O, Saruhan-Direskeneli G, Uyar F A, Günoz H, Gorodezky C, Alaez C, Boehm B O, Mlynarski W, Ikegami H, Berrino M, Fasano M E, Dametto E, Israel S, Brautbar C, Santiago-Cortes A, Frazer de Llado T, She J-X, Bugawan T L, Rotter J I, Raffel L, Zeidler A, Leyva-Cobian F, Hawkins B R, Chan S H, Castano L, Pociot F, Nerup J
Abstract excerpt
The direct involvement of the human leukocyte antigen class II DR-DQ genes in type 1 diabetes (T1D) is well established, and these genes display a complex hierarchy of risk effects at the genotype and haplotype levels. We investigated, using data from 38 studies, whether the DR-DQ haplotypes and genotypes show the same relative predispositional effects across populations and ethnic groups. Significant differences...
Topics
- Diabetes Mellitus, Type 1
- Europe
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
- HLA-DQ beta-Chains