HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.

doi:10.1034/j.1399-0039.2000.550312.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.

Tissue antigens - 1 Mar 2000

Donner H, Seidl C, Van der Auwera B, Braun J, Siegmund T, Herwig J, Weets I, Usadel K H, Badenhoop K

Abstract excerpt

HLA-DR4 is a primary disease association marker in type 1 diabetes mellitus (IDDM). We therefore analyzed the transmission of 228 DR4+ haplotypes in 183 families with an IDDM proband (95 from Germany and 88 from Belgium). In a separate case-control data set, we investigated the HLA-DRB1*04 and DQ allele distribution in 245 IDDM patients and 177 controls from Germany, all DR4 positive. HLA-DRB1 *0401 and *0402...

Topics

Adolescent
Adult
Belgium
Case-Control Studies
Child
Child, Preschool
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Genetic Predisposition to Disease
Germany

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ Antigens

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DRB1 Chains

Humans

Infant

Source

Open in PubMed

Identifiers

PMID: 10777104
DOI: 10.1034/j.1399-0039.2000.550312.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.PMID 10777104Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.Semantic proximity Read ↗

Relative and absolute HLA-DQA1-DQB1 linked risk for developing type I diabetes before 40 years of age in the Belgian population: implications for future prevention studies.Semantic proximity Read ↗

Association of particular HLA class II alleles, haplotypes and genotypes with susceptibility to IDDM in the Belgian population.Semantic proximity Read ↗

Increased and decreased relative risk for non-insulin-dependent diabetes mellitus conferred by HLA class II and by CD4 alleles.Semantic proximity Read ↗

HLA-DRB1*0403 is associated with dominant protection against IDDM in the general Dutch population and subjects with high-risk DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype.Semantic proximity Read ↗

Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian population.Semantic proximity Read ↗

Contribution of DRB1*04 variants to predisposition to or protection from insulin dependent diabetes mellitus is independent of dq.Semantic proximity Read ↗

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania.Semantic proximity Read ↗

Genetic susceptibility to type 1 diabetes: clinical and molecular heterogeneity of IDDM1 and IDDM12 in a german population.Semantic proximity Read ↗

The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.