Article
A peptide antagonist disrupts NK cell inhibitory synapse formation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2013
Borhis Gwenoline, Ahmed Parvin S, Mbiribindi Bérénice, Naiyer Mohammed M, Davis Daniel M, Purbhoo Marco A, Khakoo Salim I
Abstract excerpt
Productive engagement of MHC class I by inhibitory NK cell receptors depends on the peptide bound by the MHC class I molecule. Peptide:MHC complexes that bind weakly to killer cell Ig-like receptors (KIRs) can antagonize the inhibition mediated by high-affinity peptide:MHC complexes and cause NK cell activation. We show that low-affinity peptide:MHC complexes stall inhibitory signaling at the step of Src homology...
Topics
- Cell Line
- Killer Cells, Natural
- Mutation
- Peptides
- Phenylalanine
- Protein Binding
- Receptors, KIR2DL3
- Signal Transduction
- Synapses