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Article

A peptide antagonist disrupts NK cell inhibitory synapse formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2013

Borhis Gwenoline, Ahmed Parvin S, Mbiribindi Bérénice, Naiyer Mohammed M, Davis Daniel M, Purbhoo Marco A, Khakoo Salim I

Abstract excerpt

Productive engagement of MHC class I by inhibitory NK cell receptors depends on the peptide bound by the MHC class I molecule. Peptide:MHC complexes that bind weakly to killer cell Ig-like receptors (KIRs) can antagonize the inhibition mediated by high-affinity peptide:MHC complexes and cause NK cell activation. We show that low-affinity peptide:MHC complexes stall inhibitory signaling at the step of Src homology...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23382564
DOI: 10.4049/jimmunol.1201032
PMCID: PMC3672982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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