Article
The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2005
Huang Hon-Ren, Rowe Claire E, Mohr Sabine, Jiang Yue, Lambowitz Alan M, Perlman Philip S
Abstract excerpt
Group I and II introns self-splice in vitro, but require proteins for efficient splicing in vivo, to stabilize the catalytically active RNA structure. Recent studies showed that the splicing of some Neurospora crassa mitochondrial group I introns additionally requires a DEAD-box protein, CYT-19, which acts as an RNA chaperone to resolve nonnative structures formed during RNA folding. Here we show that, in...
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