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Article

Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.

Nucleic acids research - 11 Jun 1994

Moran J V, Mecklenburg K L, Sass P, Belcher S M, Mahnke D, Lewin A, Perlman P

Abstract excerpt

Six mutations blocking the function of a seven intron form of the mitochondrial gene encoding subunit I of cytochrome c oxidase (COXI) and mapping upstream of exon 3 were isolated and characterized. A cis-dominant mutant of the group IIA intron 1 defines a helical portion of the C1 substructure of domain 1 as essential for splicing. A trans-recessive mutant confirms that the intron 1 reading frame encodes a...

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Identifiers

PMID: 8029012
DOI: 10.1093/nar/22.11.2057
PMCID: PMC308121

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Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.PMID 8029012Read ↗

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