Article
Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.
Nucleic acids research - 11 Jun 1994
Moran J V, Mecklenburg K L, Sass P, Belcher S M, Mahnke D, Lewin A, Perlman P
Abstract excerpt
Six mutations blocking the function of a seven intron form of the mitochondrial gene encoding subunit I of cytochrome c oxidase (COXI) and mapping upstream of exon 3 were isolated and characterized. A cis-dominant mutant of the group IIA intron 1 defines a helical portion of the C1 substructure o...
Topics
- Base Sequence
- DNA, Fungal
- DNA, Mitochondrial
- Electron Transport Complex IV
- Endoribonucleases
- Genes, Fungal
- Genetic Complementation Test
- Introns
- Molecular Sequence Data
- Mutation
- Nucleotidyltransferases
- Open Reading Frames
- RNA Splicing
- RNA, Fungal
- Restriction Mapping