Article
Deletions in the extracellular domain of rat trkA lead to an altered differentiative phenotype in neurotrophin responsive cells.
Molecular and cellular neurosciences - 1 May 1996
MacDonald J I, Meakin S O
Abstract excerpt
We have investigated the role(s) of conserved sequences in the extracellular domain of rat trkA by generating 5' and 3' deletions and assaying changes in neurotrophin binding, tyrosine kinase activity, and neurite outgrowth. Essential sequences required for both nerve growth factor (NGF) and neur...
Topics
- Animals
- Binding, Competitive
- Cell Differentiation
- Dose-Response Relationship, Drug
- Gene Deletion
- Gene Expression
- Ligands
- Mutagenesis
- Nerve Growth Factors
- Neurotrophin 3
- PC12 Cells
- Phenotype
- Phosphorylation
- Protein Structure, Tertiary
- Rats
- Receptor, trkA