Article
Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Mar 1996
Lindsay R M
Abstract excerpt
The neurotrophins are a family of polypeptide neuronal growth factors related to the prototypical neurotrophic factor, nerve growth factor (NGF). In mammals this gene family encompasses NGF, brain-derived neurotrophic factor (BDNF) and neurotrophins-3 and -4/5, (NT-3, NT-4/5). The neurotrophins initiate signal transduction in responsive cells by ligand induced dimerization and activation of one of the Trk family...
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