Article
Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins.
Neuron - 1 Jun 1995
Curtis R, Adryan K M, Stark J L, Park J S, Compton D L, Weskamp G, Huber L J, Chao M V, Jaenisch R, Lee K F
Abstract excerpt
The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of...
Topics
- Animals
- Axonal Transport
- Binding Sites
- Biological Transport
- Brain-Derived Neurotrophic Factor
- Ganglia, Spinal
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Motor Neurons
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurons, Afferent
- Rats
- Rats, Sprague-Dawley
- Receptor Protein-Tyrosine Kinases