Article
TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells.
The European journal of neuroscience - 1 Jun 1995
Inagaki N, Thoenen H, Lindholm D
Abstract excerpt
The proto-oncogene product gp140prototrk (TrkA) is the receptor tyrosine kinase that mediates nerve growth factor-induced neuronal survival and differentiation. In receptor tyrosine kinases, specific intracellular tyrosine residues become phosphorylated after ligand binding and the phosphorylated tyrosines induce the cascade of signal transduction. Here we have identified intracellular tyrosine residues of TrkA...
Topics
- Animals
- Intracellular Membranes
- Mutagenesis, Site-Directed
- Mutation
- Nerve Growth Factors
- Neurites
- Neurons
- PC12 Cells
- Peptide Fragments
- Proto-Oncogene Proteins
- Rats
- Receptor Protein-Tyrosine Kinases