Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells.

The European journal of neuroscience - 1 Jun 1995

Inagaki N, Thoenen H, Lindholm D

Abstract excerpt

The proto-oncogene product gp140prototrk (TrkA) is the receptor tyrosine kinase that mediates nerve growth factor-induced neuronal survival and differentiation. In receptor tyrosine kinases, specific intracellular tyrosine residues become phosphorylated after ligand binding and the phosphorylated tyrosines induce the cascade of signal transduction. Here we have identified intracellular tyrosine residues of TrkA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutagenesis, Site-Directed
Share to Mutation
Share to Neurons

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Fragments

Share to Proto-Oncogene Proteins

Share to Receptor Protein-Tyrosine Kinases

Share to Tyrosine

Source

Identifiers

PMID: 7582085
DOI: 10.1111/j.1460-9568.1995.tb01102.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells.PMID 7582085Read ↗

A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation.Semantic proximity Read ↗

TrkA NGF receptor plays a role in the modulation of p75NTR expression.Semantic proximity Read ↗

Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.Semantic proximity Read ↗

A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.Semantic proximity Read ↗

Protein tyrosine phosphatase receptor type Z dephosphorylates TrkA receptors and attenuates NGF-dependent neurite outgrowth of PC12 cells.Semantic proximity Read ↗

Functional expression of TrkA receptors in hippocampal neurons.Semantic proximity Read ↗

Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.Semantic proximity Read ↗

A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.Semantic proximity Read ↗

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.Semantic proximity Read ↗

Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.Semantic proximity Read ↗

Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells.Semantic proximity Read ↗

Deletions in the extracellular domain of rat trkA lead to an altered differentiative phenotype in neurotrophin responsive cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.