Article
Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling.
The EMBO journal - 1 May 1995
Rydén M, Murray-Rust J, Glass D, Ilag L L, Trupp M, Yancopoulos G D, McDonald N Q, Ibáñez C F
Abstract excerpt
The neurotrophins mediate their effects through binding to two classes of receptors, a tyrosine kinase receptor, member of the Trk family, and the low-affinity neurotrophin receptor, p75LNGFR, of as yet undefined signalling capacity. The need for a two-component receptor system in neurotrophin signalling is still not understood. Using site-directed mutagenesis, we have identified positively charged surfaces in...
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