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Article

Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons.

Clinical and experimental pharmacology & physiology - 1 Apr 2003

Murray Simon S, Bartlett Perry F, Lopes Elizabeth C, Coulson Elizabeth J, Greferath Una, Cheema Surindar S

Abstract excerpt

1. In vivo studies have shown that the low-affinity 75 kDa neurotrophin receptor (p75NTR) is involved in axotomy-induced cell death of sensory and motor neurons. To further examine the importance of p75NTR in mediating neuronal death in vivo, we examined the effect of axotomy in the p75NTR-knockout mouse, which has a disrupted ligand-binding domain. 2. The extent of sensory and motor neuron loss in the...

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Identifiers

PMID: 12680838
DOI: 10.1046/j.1440-1681.2003.03827.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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