Article
Microheterogeneity in HLA-B35 alleles influences peptide-dependent allorecognition by cytotoxic T cells but not binding of a peptide-restricted monoclonal antibody.
Human immunology - 1 Dec 1993
Steinle A, Reinhardt C, Nössner E, Uchanska-Ziegler B, Ziegler A, Schendel D J
Abstract excerpt
Strong peptide dependency of HLA-B*3501-specific alloreactive T-cell clones was observed in the recognition of cells bearing closely related B35 variants. The single amino acid exchange in the beta-pleated sheet of B*3503 completely abolished the responses of all clones, whereas an amino acid exchange in the alpha 2 helix of the newest B35 member (B*3508) only altered allorecognition of one T-cell clone,...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Binding, Competitive
- Cell Line
- Genotype
- HLA-B35 Antigen
- Humans
- Molecular Sequence Data
- Peptides
- T-Lymphocytes, Cytotoxic