Article
Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self peptide.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1994
Pullen J K, Tallquist M D, Melvold R W, Pease L R
Abstract excerpt
The transcripts encoding two strongly alloantigenic class I mutant molecules, Kdm4 and Kdm5, were characterized and found to encode products that differ from the parental Kd glycoprotein by single amino acid substitutions. The Kdm4 molecule has an amino acid change at position 114, an integral co...
Topics
- Amino Acid Sequence
- Animals
- Autoantigens
- Base Sequence
- Binding Sites
- Female
- H-2 Antigens
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Peptides
- RNA Splicing