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Article

Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Di Marco A, Gloaguen I, Graziani R, Paonessa G, Saggio I, Hudson K R, Laufer R

Abstract excerpt

Ciliary neurotrophic factor (CNTF) drives the sequential assembly of a receptor complex containing the ligand-specific alpha-receptor subunit (CNTFR alpha) and the signal transducers gp130 and leukemia inhibitory factor receptor-beta (LIFR). The D1 structural motif, located at the beginning of the D-helix of human CNTF, contains two amino acid residues, F152 and K155, which are conserved among all cytokines that...

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Source

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Identifiers

PMID: 8799186
DOI: 10.1073/pnas.93.17.9247
PMCID: PMC38627

Genes

CNTF
CNTFR
LIFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.PMID 8799186Read ↗

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