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Article

CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction.

The EMBO journal - 3 Jul 1995

Saggio I, Gloaguen I, Poiana G, Laufer R

Abstract excerpt

Human CNTF is a neurocytokine that elicits potent neurotrophic effects by activating a receptor complex composed of the ligand-specific alpha-receptor subunit (CNTFR alpha) and two signal transducing proteins, which together constitute a receptor for leukemia inhibitory factor (LIFR). At high concentrations, CNTF can also activate the LIFR and possibly other cross-reactive cytokine receptors in the absence of...

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Source

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Identifiers

PMID: 7621819
DOI: 10.1002/j.1460-2075.1995.tb07307.x
PMCID: PMC394365

Genes

CNTF
CNTFR
LIFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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