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Article

CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction.

The EMBO journal - 3 Jul 1995

Saggio I, Gloaguen I, Poiana G, Laufer R

Abstract excerpt

Human CNTF is a neurocytokine that elicits potent neurotrophic effects by activating a receptor complex composed of the ligand-specific alpha-receptor subunit (CNTFR alpha) and two signal transducing proteins, which together constitute a receptor for leukemia inhibitory factor (LIFR). At high concentrations, CNTF can also activate the LIFR and possibly other cross-reactive cytokine receptors in the absence of...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Binding, Competitive
Chick Embryo
Ciliary Neurotrophic Factor
Cytotoxicity Tests, Immunologic
Dose-Response Relationship, Immunologic
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Haptoglobins

Humans

Ligands

Molecular Sequence Data

Nerve Growth Factors

Nerve Tissue Proteins

Point Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7621819
DOI: 10.1002/j.1460-2075.1995.tb07307.x
PMCID: PMC394365

Genes

CNTF
CNTFR
LIFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7621819-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction.PMID 7621819Read ↗

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