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Article

Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006

Rousseau François, Gauchat Jean-François, McLeod James G, Chevalier Sylvie, Guillet Catherine, Guilhot Florence, Cognet Isabelle, Froger Josy, Hahn Angelika F, Knappskog Per M, Gascan Hugues, Boman Helge

Abstract excerpt

Ciliary neurotrophic factor (CNTF) receptor controls a pathway supporting the differentiation and survival of a wide range of neural cell types during development and in adulthood. Cardiotrophin-like cytokine (CLC)-cytokine-like factor 1 (CLF) composite cytokine is a second ligand for the CNTF alpha-component receptor (CNTFRalpha). This composite cytokine is built on the structural model of IL-12, with a complex...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16782820
DOI: 10.1073/pnas.0509598103
PMCID: PMC1502507

Genes

CLC
CNTF
CLCF1
CRLF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.PMID 16782820Read ↗

CRLF1 and CLCF1 in Development, Health and DiseaseSemantic proximity Read ↗

Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.Semantic proximity Read ↗

Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1.Semantic proximity Read ↗

Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.Semantic proximity Read ↗

Mutations in CRLF1 cause familial achalasia.Semantic proximity Read ↗

Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome.Semantic proximity Read ↗

IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants.Semantic proximity Read ↗

Three new cases of Crisponi /cold induced sweating syndrome (CS/CISS1) in Turkish families.Semantic proximity Read ↗

Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene.Semantic proximity Read ↗

Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.Semantic proximity Read ↗

Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.Semantic proximity Read ↗

CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction.Semantic proximity Read ↗

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