Article
Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma.
Nature medicine - 1 Nov 2019
Kim Jun W, Marquez Cesar P, Kostyrko Kaja, Koehne Amanda L, Marini Kieren, Simpson David R, Lee Alex G, Leung Stanley G, Sayles Leanne C, Shrager Joseph, Ferrer Irene, Paz-Ares Luis, Gephart Melanie Hayden, Vicent Silvestre, Cochran Jennifer R, Sweet-Cordero E Alejandro
Abstract excerpt
Proinflammatory cytokines in the tumor microenvironment can promote tumor growth, yet their value as therapeutic targets remains underexploited. We validated the functional significance of the cardiotrophin-like cytokine factor 1 (CLCF1)-ciliary neurotrophic factor receptor (CNTFR) signaling axis in lung adenocarcinoma (LUAD) and generated a high-affinity soluble receptor (eCNTFR-Fc) that sequesters CLCF1,...
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