Article
Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine.
The Journal of biological chemistry - 7 Sept 2001
Mizoue L S, Sullivan S K, King D S, Kledal T N, Schwartz T W, Bacon K B, Handel T M
Abstract excerpt
Fractalkine/CX3CL1 is a membrane-tethered chemokine that functions as a chemoattractant and adhesion protein by interacting with the receptor CX3CR1. To understand the molecular basis for the interaction, an extensive mutagenesis study of fractalkine's chemokine domain was undertaken. The results reveal a cluster of basic residues (Lys-8, Lys-15, Lys-37, Arg-45, and Arg-48) and one aromatic (Phe-50) that are...
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