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Article

IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants.

Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2010

Rousseau Francois, Basset Laetitia, Froger Josy, Dinguirard Nathalie, Chevalier Sylvie, Gascan Hugues

Abstract excerpt

IL-27, consisting of the subunits IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), is a heterodimeric cytokine belonging to the IL-6/IL-12 family of cytokines. IL-27p28 is a four-helical cytokine requiring association with the soluble receptor EBI3 to be efficiently secreted and functionall...

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Source

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Identifiers

PMID: 20974977
DOI: 10.1073/pnas.1005793107
PMCID: PMC2984150

Genes

EBI3
CNTF
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20974977-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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