Article

Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder

2024-02-08

Abstract excerpt

<title>Abstract</title> <p>Background Mutations in the X-linked <italic>CDKL5</italic> gene underlie a severe epileptic encephalopathy, CDKL5 deficiency disorder (CDD), characterized by gross motor impairment, autistic features and intellectual disability. Absence of Cdkl5 negatively impacts neuronal proliferation, survival, and maturation in in vitro and in vivo models, resulting in behavioral deficits in the <...

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Literature Corpus work: cb471e04-5c0e-58fc-b8cf-749599399760
DOI: 10.21203/rs.3.rs-3897288/v1

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