Article
New approach for inhibiting Rev function and HIV-1 production using the influenza virus NS1 protein.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996
Qian X Y, Chen Z Y, Zhang J, Rabson A B, Krug R M
Abstract excerpt
The Rev protein of HIV-1, which facilitates the nuclear export of HIV-1 pre-mRNAs, has been a target for antiviral therapy. Here we describe a new strategy for inhibiting Rev function and HIV-1 replication. In contrast to previous approaches, we use a wild-type rather than a mutant Rev protein and covalently link this Rev sequence to the NS1 protein of influenza A virus, a protein that inhibits the nuclear export...
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