Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.

Journal of virology - 1 Oct 2000

Bogerd H P, Wiegand H L, Yang J, Cullen B R

Abstract excerpt

Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endogenous Retroviruses
Share to Exportin 1 Protein
Share to Gene Products, rev

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Karyopherins

Share to Receptors, Cytoplasmic and Nuclear

Share to rev Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 11000203
DOI: 10.1128/jvi.74.20.9353-9361.2000
PMCID: PMC112363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.PMID 11000203Read ↗

Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope ProteinSemantic proximity Read ↗

Cooperativity among Rev-Associated Nuclear Export Signals Regulates HIV-1 Gene Expression and Is a Determinant of Virus Species TropismSemantic proximity Read ↗

Genomic Flexibility of Human Endogenous Retrovirus Type KSemantic proximity Read ↗

Mutational definition of the human immunodeficiency virus type 1 Rev activation domainSemantic proximity Read ↗

New approach for inhibiting Rev function and HIV-1 production using the influenza virus NS1 protein.Semantic proximity Read ↗

Identification of a homogenous structural basis for oligomerization by retroviral Rev-like proteins.Semantic proximity Read ↗

Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.Semantic proximity Read ↗

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.Semantic proximity Read ↗

Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminusSemantic proximity Read ↗

HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.Semantic proximity Read ↗

HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNASemantic proximity Read ↗

HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.