Article
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.
Cell - 11 Aug 1995
Bogerd H P, Fridell R A, Madore S, Cullen B R
Abstract excerpt
HIV-1 Rev is the prototype of a class of retroviral regulatory proteins that induce the sequence-specific nuclear export of target RNAs. This function requires the Rev activation domain, which is believed to bind an essential cellular cofactor. We report the identification of a novel human gene product that binds to not only the HIV-1 Rev activation domain in vitro and in vivo but also to functionally equivalent...
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