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Article

HIV-1 resists MxB inhibition of viral Rev protein.

Emerging microbes & infections - 1 Dec 2020

Wang Zhen, Chai Keli, Liu Qian, Yi Dong-Rong, Pan Qinghua, Huang Yu, Tan Juan, Qiao Wentao, Guo Fei, Cen Shan, Liang Chen

Abstract excerpt

The interferon-inducible myxovirus resistance B (MxB) protein has been reported to inhibit HIV-1 and herpesviruses by blocking the nuclear import of viral DNA. Here, we report a new antiviral mechanism in which MxB restricts the nuclear import of HIV-1 regulatory protein Rev, and as a result, diminishes Rev-dependent expression of HIV-1 Gag protein. Specifically, MxB disrupts the interaction of Rev with the...

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Share to Active Transport, Cell Nucleus
Share to beta Karyopherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Gene Products, gag

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Share to rev Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 32873191
DOI: 10.1080/22221751.2020.1818633
PMCID: PMC7534208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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