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Article

Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element.

Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008

Legiewicz Michal, Badorrek Christopher S, Turner Kevin B, Fabris Daniele, Hamm Tiffany E, Rekosh David, Hammarskjöld Marie-Louise, Le Grice Stuart F J

Abstract excerpt

Nuclear export of certain HIV-1 mRNAs requires an interaction between the viral Rev protein and the Rev response element (RRE), a structured element located in the Env region of its RNA genome. This interaction is an attractive target for both drug design and gene therapy, exemplified by RevM10, a transdominant negative protein that, when introduced into host cells, disrupts viral mRNA export. However, two silent...

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Share to Drug Resistance, Viral
Share to Genes, env

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mass Spectrometry

Share to Nucleic Acid Conformation

Share to rev Gene Products, Human Immunodeficiency Virus

Share to RNA, Viral

Share to Virus Replication

Source

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Identifiers

PMID: 18776047
DOI: 10.1073/pnas.0804461105
PMCID: PMC2567145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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