Article
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Hope T J, Huang X J, McDonald D, Parslow T G
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) transactivator Rev is a nuclear protein that regulates expression of certain HIV-1 transcripts by binding to an RNA target element (the RRE) present in these transcripts. A short arginine-rich sequence in Rev contains the signals required to direct this protein into nuclei, where it associates preferentially with nucleoli. We created a steroid-inducible...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Chimera
- Gene Products, rev
- Genes, Viral
- Genes, rev
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation