Article
Exchange of functional domains between Rev proteins of HIV-1 and SIVmac239 results in a dominant negative phenotype.
Virology - 1 Oct 1994
Berchtold S, Ries J, Hornung U, Aepinus C
Abstract excerpt
The Rev proteins of primate immunodeficiency viruses are essential transactivators to switch from early to late phase in the viral replication cycle. Surprisingly, the Rev protein of HIV-1 is able to substitute those of HIV-2 and, as shown in here, of SIVmac239, but not vice versa. To understand...
Topics
- Amino Acid Sequence
- Cell Line
- Gene Products, rev
- Genes, Reporter
- Genetic Complementation Test
- HIV-1
- Luciferases
- Molecular Sequence Data
- Phenotype
- Protein Conformation
- RNA, Viral
- Recombinant Fusion Proteins