trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes.

Abstract excerpt

The human immunodeficiency virus type 1 Rev protein controls expression of certain viral RNAs by binding to these RNAs in the nucleus. To investigate how dominant negative Rev mutants inhibit Rev function, we fused such mutants to hormone-dependent localization signals from the glucocorticoid rec...

Topics

• Binding, Competitive
• Blotting, Western
• Cell Line
• Fluorescent Antibody Technique
• Gene Products, rev
• HIV-1
• Humans
• Mutation
• Transcriptional Activation
• rev Gene Products, Human Immunodeficiency Virus