Article
Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.
Molecular and cellular biology - 1 Oct 1991
Lazar M A, Berrodin T J, Harding H P
Abstract excerpt
Binding of the thyroid hormone receptor (TR) to thyroid hormone-responsive elements (TREs) is crucial for regulation of gene expression by thyroid hormone. The TR binds to each half-site of a palindromic TRE separately, as a monomer, or simultaneously, as a homodimer. In addition, the TR monomer interacts with a 42-kDa protein that may be responsible for an increase in the apparent size and stability of the...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Western
- DNA
- Escherichia coli
- Kinetics
- Liver Extracts
- Macromolecular Substances
- Molecular Sequence Data
- Mutation