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Article

Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.

Molecular and cellular biology - 1 Oct 1991

Lazar M A, Berrodin T J, Harding H P

Abstract excerpt

Binding of the thyroid hormone receptor (TR) to thyroid hormone-responsive elements (TREs) is crucial for regulation of gene expression by thyroid hormone. The TR binds to each half-site of a palindromic TRE separately, as a monomer, or simultaneously, as a homodimer. In addition, the TR monomer interacts with a 42-kDa protein that may be responsible for an increase in the apparent size and stability of the...

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Identifiers

PMID: 1922030
DOI: 10.1128/mcb.11.10.5005-5015.1991
PMCID: PMC361489

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