Article
Protein-protein interaction domains and the heterodimerization of thyroid hormone receptor variant alpha2 with retinoid X receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1998
Wu Y, Yang Y Z, Koenig R J
Abstract excerpt
Heterodimerization between thyroid hormone receptors (TRs) and retinoid X receptors (RXRs) is mediated by a weak dimerization interface within the DNA- binding domains (DBDs) and a strong interface within the C-terminal ligand- binding domains of the receptors. Previous studies have shown that th...
Topics
- Amino Acid Sequence
- Binding Sites
- DNA
- Dimerization
- Molecular Sequence Data
- Mutation
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Recombinant Proteins
- Response Elements
- Retinoid X Receptors
- Transcription Factors