Article
The unique C-termini of the thyroid hormone receptor variant, c-erbA alpha 2, and thyroid hormone receptor alpha 1 mediate different DNA-binding and heterodimerization properties.
Molecular endocrinology (Baltimore, Md.) - 1 May 1992
Katz D, Berrodin T J, Lazar M A
Abstract excerpt
Thyroid hormone receptors (TRs) mediate the regulation of gene transcription by thyroid hormone (T3) by binding to T3-responsive elements (TREs) in target genes. c-erbA alpha 2 is a C-terminal TR variant which does not bind T3 and is a dominant inhibitor of T3 action. When synthesized in Escheric...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Mutational Analysis
- DNA-Binding Proteins
- Genetic Variation
- Macromolecular Substances
- Molecular Sequence Data
- Proto-Oncogene Proteins
- Rats
- Receptors, Thyroid Hormone
- Structure-Activity Relationship