Article
Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element.
Endocrinology - 1 Apr 1996
Zavacki A M, Zhang C Y, Harney J W, Larsen P R
Abstract excerpt
The two isoforms of thyroid hormone receptor (TR), alpha and beta, are highly homologous, except in the amino-terminal domain. Specific physiological roles for the receptor isoforms have not yet been defined. In transient transfection assays, TRalpha is twice as potent a thyroid hormone (T3)-depe...
Topics
- Animals
- Base Sequence
- DNA
- DNA Transposable Elements
- Isomerism
- Ligands
- Mice
- Molecular Sequence Data
- Mutation
- Osmolar Concentration
- Promoter Regions, Genetic
- Receptors, Thyroid Hormone
- Transcriptional Activation
- Triiodothyronine