Amino acid substitutions of thyroid hormone receptor-beta at codon 435 with resistance to thyroid hormone selectively alter homodimer formation.

doi:10.1210/endo.137.10.8828460

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Article

Amino acid substitutions of thyroid hormone receptor-beta at codon 435 with resistance to thyroid hormone selectively alter homodimer formation.

Endocrinology - 1 Oct 1996

Nomura Y, Nagaya T, Tsukaguchi H, Takamatsu J, Seo H

Abstract excerpt

Thyroid hormone action is mediated through its nuclear receptors (TRs), which bind to target DNA sequences [thyroid hormone response element (TRE)] as a homodimer or a heterodimer with 9-cis-retinoic acid receptors. Mutations of TR beta identified in patients with resistance to thyroid hormone (RTH) cluster primarily at two areas separated by the putative dimerization region. Two TR beta mutations were newly...

Topics

Amino Acid Sequence
Codon
DNA
Dimerization
Drug Resistance
Genes, Dominant
Humans
Mutation
Receptors, Thyroid Hormone
Transcription, Genetic
Triiodothyronine

Source

Open in PubMed

Identifiers

PMID: 8828460
DOI: 10.1210/endo.137.10.8828460

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