Article
Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients.
Cancer research - 15 Sept 1996
Taubert H, Meye A, Würl P
Abstract excerpt
We investigated the prognostic value of p53 mutation type for 145 soft tissue sarcoma patients. In a PCR-SSCP-sequencing analysis, 15 mutations were identified: 10 non-frameshift (non-fs) and 5 frameshift (fs) mutations. Patients possessing non-fs mutations had a significantly poorer prognosis than patients without p53 mutations (P = 0.014), according to Cox's multivariate analysis. In contrast, the survival of...
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