Article
HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae.
Yeast (Chichester, England) - 1 Jan 1996
Noskov V N, Staak K, Shcherbakova P V, Kozmin S G, Negishi K, Ono B C, Hayatsu H, Pavlov Y I
Abstract excerpt
The ham1 mutant of yeast Saccharomyces cerevisiae is sensitive to the mutagenic and lethal effects of the base analog, 6-N-hydroxylaminopurine (HAP). We have isolated a clone from a centromere-plasmid-based genomic library complementing HAP sensitivity of the ham1 strain. After subcloning, a 3.4...
Topics
- Adenine
- Amino Acid Sequence
- Cloning, Molecular
- DNA, Fungal
- Drug Resistance, Microbial
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Mutagenesis
- Mutagens
- Open Reading Frames
- Phenotype
- Restriction Mapping
- Saccharomyces cerevisiae