Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.

Genetics - 1 Jul 2000

Scheller J, Schürer A, Rudolph C, Hettwer S, Kramer W

Abstract excerpt

We have characterized the MPH1 gene from Saccharomyces cerevisiae. mph1 mutants display a spontaneous mutator phenotype. Homologs were found in archaea and in the EST libraries of Drosophila, mouse, and man. Mph1 carries the signature motifs of the DEAH family of helicases. Selected motifs were shown to be necessary for MPH1 function by introducing missense mutations. Possible indirect effects on translation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to DNA Damage
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fungal Proteins

Share to Genome, Fungal

Share to Mutagenicity Tests

Share to RNA Helicases

Source

Open in PubMed Open full text

Identifiers

PMID: 10880470
DOI: 10.1093/genetics/155.3.1069
PMCID: PMC1461162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.PMID 10880470Read ↗

Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.Semantic proximity Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion.Semantic proximity Read ↗

HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis.Semantic proximity Read ↗

The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.Semantic proximity Read ↗

KDM6A mutations promote acute cytoplasmic DNA release, DNA damage response and mitosis defectsSemantic proximity Read ↗

Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.Semantic proximity Read ↗

Hof1 plays a checkpoint-related role in MMS-induced DNA damage response in Candida albicans.Semantic proximity Read ↗

Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21.Semantic proximity Read ↗

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch RepairSemantic proximity Read ↗

Epigenetic regulation of genome integrity by a prion-based mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.